Dieser Artikel der Mayo Clinic erklärt den medikamenten-induzierten Kopfschmerz (MIK, Rebound Headache) wie folgt:
"When you take pain medicine daily, even if it's just an over-the-counter remedy, your body can gradually become accustomed to it. You may not realize that you've been dosing yourself too often until, for some reason, you miss a day. Then your pain medicine will wear off and your head will start hurting again. You may think you just have an especially persistent headache, but the recurring pain actually is a symptom of medication withdrawal. The more often your head hurts, the more often you take your pain medicine. It becomes a vicious cycle."