Eine Studie prüfte die These, dass es sich bei Migräne um eine Reizverarbeitungsstörung im Gehirn handele und dass Migräniker besonders sensibel auf Reize reagieren würden.
Dazu wurden 24 Migräniker, 19 Personen mit Spannungskopfschmerzen und 24 gesunde Kontrollen diversen Reizen ausgesetzt, die sie nach Stärke und bzgl. unangenehmer Wirkung einstufen sollten. Kein Test konnte die vorausgesagte Hypersensibilität der Migräniker bestätigen.
Abstract:
Are migraineurs hypersensitive? A test of the stimulus processing disorder hypothesis.
Kroner-Herwig B, Ruhmland M, Zintel W, Siniatchkin M.
Department of Clinical Psychology and Psychotherapy, University of Goettingen, Gosslerstreet 14, 37073 Goettingen, Germany.
The concept of hypersensitivity in migraineurs was advanced mainly on the basis of studies on information processing in which increased amplitudes and reduced habituation in cortical evoked and event related potentials were found in migraine sufferers. The present investigation examined whether migraineurs exhibit hypersensitivity within three different experimental paradigms and various non electrocortical response parameters. Samples of 24 migraine, 19 tension-type headache sufferers, and 24 normal controls were compared regarding their subjective estimation of intensity and discomfort due to visual and acoustical stimuli. Subjects also participated in an experiment using the eyeblink startle response paradigm. In a last experimental task the Stroop test was applied. The trait variables emotionality, arousal, and extraversion were also measured. None of the experimental tasks revealed the predicted hypersensitivity of migraineurs in relation to the control samples. The series of experiments was conducted a second time with half of the participants in order to replicate the findings. The conclusions remained the same. The results of earlier studies on cortical processing can not be interpreted as demonstrating general hypersensitivity in the sense of a dispositional trait in migraine afflicted individuals irrespective of the involved response system.
Kroner-Herwig B, Ruhmland M, Zintel W, Siniatchkin M. Are migraineurs hypersensitive? A test of the stimulus processing disorder hypothesis. Eur J Pain. 2005 Dec;9(6):661-71. Epub 2005 Jan 19.
Weitere Infos finden sich hier.