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Alzheimer-Mittel Memantin Hydrochlorid möglicherweise auch bei chronischer Migräne und Spannungskopfschmerzen wirksam [Pharma]
08 Nov 05
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Mittel wirkt als sog. NMDA Glutamat Rezeptor-Angonist |
Eine erste Open-Label-Studie in den USA hat eine Wirkung des Alzheimer-Mittels Memantin Hydrochlorid (Markennamen: Ebixa, Axura, Namenda) bei chronischer Migräne und chronischen Spannungskopfschmerzen gezeigt. Bei 14 von insgesamt 20 Patienten, die auf keine übliche Medikamentation ansprachen, konnte eine Verbesserung der Migräne-Häufigkeit um 56% beobachtet werden.
Abstract:
Twenty patients with chronic Migraines who had not responded to other prophylaxis measures were studied. They had an average of 9.2 Migraines per month. Fourteen of 20 (60%) had TTH as well (average of 12.5 days per month). Memantine was added at 5mg per day with weekly increases of 5 mg, up to a maximum of 20 mg per day, as tolerated. Patients kept headache diaries for Migraines and TTH as well as pain scores. Evaluations were made after one month of therapy on 20 mg (or maximally tolerated dose) of memantine.
The average length of treatment, including the initial titration of memantine dosage, was 4.6 months, with an average daily dosage of 19.25mg (range= 10-20mg/day). Migraine frequency fell to an average of 4.1 Migraines per month, or almost 56% less than at baseline, in 14 of 20 patients. Remaining Migraines were rated as less severe and easier to treat. Acute Migraine and rescue medication use dropped by two-thirds. TTH frequency fell by 62%, to 6 headaches per month. 6 patients saw no response of their Migraines to memantine. 4 patients reported dizziness and one nausea. 2 of these patients had betterment of their Migraines. Acute migraine and rescue medication use dropped by two-thirds.
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