Die Studie stellt dar, dass Topiramat (Topamax) nicht nur bei Migräne und Epilepsie wirkt, sondern möglicherweise auch bei Pseudotumor cerebri. Die Verfasser weisen darauf hin, dass es unter Topamax-Anwendung zu einigen akuten Glaukoma-Erkrankungen (grüner Star) gekommen ist.
Abstract:
Topiramate, pseudotumor cerebri, weight-loss and glaucoma: an ophthalmologic perspective.
Approved for the treatment of epilepsy and migraine prophylaxis, topiramate also acts as a carbonic anhydrase inhibitor implying a potential role in the treatment of pseudotumor cerebri (PTC). Topiramate has a propensity to cause anorexia with consequent weight loss, which alone may be curative in PTC. Prescribers must be aware of several reported cases of acute secondary angle-closure glaucoma reported in patients treated with topiramate.
Alore PL, Jay WM, Macken MP: Topiramate, pseudotumor cerebri, weight-loss and glaucoma: an ophthalmologic perspective. Semin Ophthalmol. 2006 Jan-Mar;21(1):15-7.
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