A high-protein/low-carbohydrate, weight-maintaining, nonketogenic diet for 5 weeks dramatically reduced circulating glucose in people with untreated type 2 diabetes
As there has been interest in the effect of various types and amounts of dietary carbohydrates and proteins on blood glucose, on the basis of previous data, Minnesota researchers designed a high-protein/low-carbohydrate, weight-maintaining, nonketogenic diet. Its effect on glucose control in people with untreated type 2 diabetes was determined. They referred to this as a low-biologically-available-glucose diet. Eight men were studied using a randomized 5-week crossover design with a 5-week washout period. The carbohydrate:protein:fat ratio of the control diet was 55:15:30. The test diet ratio was 20:30:50.
They found that plasma and urinary ß-hydroxybutyrate were similar on both diets. The mean 24 hour integrated serum glucose at the end of the control and low-biologically-available-glucose diets was 198 and 126 mg/dl, respectively. The percentage of glycohemoglobin was 9.8 and 7.6, respectively. It was still decreasing at the end of the low-biologically-available-glucose diet. Thus, the final calculated glycohemoglobin was estimated to be approximately 6.3 - 5.4%. Serum insulin was decreased, and plasma glucagon was increased. Serum cholesterol was unchanged.
The researchers concluded: "A low-biologically-available-glucose diet ingested for 5 weeks dramatically reduced the circulating glucose concentration in people with untreated type 2 diabetes. Potentially, this could be a patient-empowering way to ameliorate hyperglycemia without pharmacological intervention. The long-term effects of such a diet remain to be determined."
Diabetes 53:2375-2382, 2004. September 2004. © 2004 by the American Diabetes Association, Inc. ICPC-2 Category T. Endocrine/Metabolic/Nutritional
"Effect of a High-Protein, Low-Carbohydrate Diet on Blood Glucose Control in People With Type 2 Diabetes", Mary C. Gannon, and Frank Q. Nuttall.
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