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Könnten Statine eine Option für die Migräneprophylaxe sein? [Pharma]
01 Mai 06
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Studie berichtet von einem Fall, bei der eine Migräne nach einer Statinbehandlung verschwand |
Die Studie spekuliert darüber, ob Statine eine prophylaktische Wirkung bei Migräne haben könnten. Immerhin gibt es klare Belege für ein erhöhtes kardiovaskuläres Risiko bei Migräne, welches durch Statine gemildert werden könnte. Die Studie berichtet ferner von einem Fallbeispiel, bei der eine Migräne nach Behandlung mit Statinen völlig verschwand.
Abstract:
Could statins be useful in the treatment of patients with migraine.
Migraine is a common and disabling neurological disorder. Studies have shown that patients with migraine (especially those with typical aura with migraine) have an unfavorable cardiovascular risk profile and an increased risk of early-onset (<45 years) ischemic stroke. Statins are effective hypolipidemic drugs that reduce cardiovascular-related morbidity and death in patients with or without established atherosclerotic vascular disease. We report a patient whose frequent attacks of typical aura with migraine completely resolved after the initiation of treatment with a statin. In this context, we comment on the possible effects of statins on the pathophysiology of migraine. We suggest that statins may be useful drugs in the treatment of migraine because they could reduce the increased cardiovascular risk in these patients and also attenuate migraine attacks. Only a randomized prospective study in this population could provide a definite answer to these speculations.
Liberopoulos EN, Mikhailidis DP. Could statins be useful in the treatment of patients with migraine. Headache. 2006 Apr;46(4):672-5.
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