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Veränderte EKG-Parameter während einer Migräneattacke [Allgemein]
14 Jun 06
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QT-Dispersion und P-Wellen-Dispersion sind erhöht |
Die QT-Dispersion, definiert als die Differenz zwischen dem längsten und dem kürzesten QT-Intervall im Oberflächen-EKG, quantifiziert das Ausmaß der räumlichen Inhomogenität der Ventrikelrepolarisation. In zahlreichen klinischen Untersuchungen bei diversen kardialen Grunderkrankungen wurde versucht, eine "pathologisch" erhöhte QT-Dispersion als Risikomarker für den plötzlichen Herztod zu etablieren.
Die Untersuchung konnte zeigen, dass bestimmte EKG-Parameter während einer Migräneattacke signifikant verändert sind, unter anderem sind die QT-Dispersion und P-Wellen-Dispersion signifikant erhöht.
Abstract:
QTc dispersion and P-wave dispersion during migraine attacks
The aim of this study was to investigate increase of QTc dispersion and P-wave dispersion during migraine attacks. Fifty-five patients (16–65 years of age, 49 women, six men) with migraine were included in our study. Heart rate, QTc interval, maximum and minimum QTc interval, QTc dispersion, maximum and minimum P-wave duration and P-wave dispersion were measured from 12-lead ECG recording during migraine attacks and pain-free periods. ECGs were transferred to a personal computer via a scanner and then used for magnification of ×400 by Adobe Photoshop software. Maximum QTc interval (454 ± 24 ms vs. 429 ± 23 ms, P < 0.001), QTc interval (443 ± 26 ms vs. 408 ± 22 ms, P < 0.001) and QTc dispersion (63 ± 18 ms vs. 43 ± 14 ms, P < 0.001) were found significantly higher during migraine attacks compared with pain-free periods. Maximum P-wave duration (107 ± 11 ms vs. 100 ± 11 ms, P < 0.001) and P-wave dispersion (45 ± 13 ms vs. 35 ± 13 ms, P < 0.001) were found higher during migraine attacks than pain-free periods. We concluded that migraine attacks are associated with increased QTc and P-wave dispersion compared with pain-free periods.
Duru, M, Melek, I, Seyfeli, E, Duman, T, Kuvandık, G, Kaya, H & Yalçın, F (2006) QTc dispersion and P-wave dispersion during migraine attacks. Cephalalgia 26 (6), 672-677. doi: 10.1111/j.1468-2982.2006.01081.x
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