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Thomapyrin verändert die Katecholamin-Ausschüttung [Pharma]
30 Apr 06

Hemmung von Dopamin und erhöhte Ausschüttung von Noradrenalin in Rattenversuchen

In Rattenversuchen konnte nach Anwendung einer Medikamentenkombination ähnlich Thomapyrin eine deutliche Reduktion der Dopamin-Ausschüttung und eine ebenfalls deutliche Erhöhung der Noradrenalin-Produktion festgestellt werden. Die Autoren schließen daraus, dass die spezielle Medikamentenkombination hierdurch Wirkungen erzielen kann, die nicht durch die Einzelwirkstoffe erreicht werden können.

Abstract:
Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine.

The fixed combination of aspirin, paracetamol (acetaminophen) and caffeine has been used successfully to treat different kinds of pain including migraine attacks. Even when this formulation has been marketed for a long time, the exact molecular mechanisms underlying its therapeutic effectiveness have not been completely elucidated. In the present investigation, we have studied the effects of the fixed combination of aspirin, paracetamol and caffeine (APC) on the release of dopamine and noradrenaline from rat striatal slices in an attempt to find potential new mechanisms of action of this widely used analgesic combination. We found that APC produced a significant reduction in extracellular dopamine and a dramatic increase in norepinephrine release from the slices incubated with different concentrations of APC (dose relationship 1:1:0.2, corresponding to the dose-relationship of Thomapyrin((R))). These findings suggest that the modulation of catecholaminergic neurotransmission is a new pharmacological effect of APC which could explain the mechanism of action of this formulation, considering that the independent effect of either compound alone does not explain the potent antinociceptive properties when observed in combination.

Fiebich BL, Candelario-Jalil E, Mantovani M, Heinzmann M, Akundi RS, Hull M, Knorle R, Schnierle P, Finkenzeller G, Aicher B. Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine. Pharmacol Res. 2006 Apr;53(4):391-6. Epub 2006 Mar 30.



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