Erniedrigte GABA-Spiegel bei chronischen Migränikern mit Depressionen [Allgemein]
01 Mai 06

GABAerge Medikamente könnten insbesondere bei chronischer Migräne mit Depressionen wirkdsam sein

14 Patienten mit chronischer Migräne, mit und ohne Depressionen wurden mit gesunden Kontrollpersonen verglichen. Dabei wurden bei den Patienten mit Depressionen signifikant niedrigere zerebrale GABA-Spiegel festgestellt.

Cerebrospinal fluid GABA levels in chronic migraine with and without depression.

Psychiatric comorbidity is one of the key elements in chronic migraine (CM) management. Depression is particularly common in these patients, occurring in up to 85%. Preclinical studies have suggested that gamma-aminobutyric acid (GABA) levels may be decreased in animal models of depression. Also, clinical studies have reported low level in mood disorder patients for both plasma and cerebrospinal fluid (CSF) GABA. We hypothesized that low GABA levels in the brain might be related to the depression associated with CM. We studied 14 chronic migraine patients, with or without depression, compared to age-and sex-matched controls. CSF GABA levels were measured by HPLC. CSF GABA levels showed significant lower levels in depressed patients than those without depression. No difference was found when comparing patients versus controls. A GABA deficiency may be the underlying mechanism of depression in CM. Hence, preventive therapies modulating GABA neurotransmission could be used in CM associated with depression.

Vieira DS, Naffah-Mazacoratti MG, Zukerman E, Senne Soares CA, Alonso EO, Faulhaber MH, Cavalheiro EA, Peres MF. Cerebrospinal fluid GABA levels in chronic migraine with and without depression. Brain Res. 2006 Apr 23.

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